Moonrollers is a game of risk assessment and strategy that pits players against each other as ship captains competing to gain crewmates.

Players begin by rolling 5 dice and must choose to attempt a requirement on an available crew card that matches one of their dice. Players commit any number of the matching dice and must choose whether to stop rolling or continue to roll their remaining dice. If they fail to roll a dice that matches a requirement they are attempting, all progress that turn is lost. If they choose to stop rolling or complete the card, their progress is saved via tokens.

Some parts of each mission are particularly hazardous, awarding players who attempt them with hazard tokens that are worth prestige at the end of the game. However, the player with the most hazard symbols is reprimanded for their chaotic conduct and is awarded no extra end-game prestige.

The end of the game is immediately triggered when a player has 3 crew of the same faction or a crew of each faction on their ship. The player with the most points won from completing requirements and from Hazards wins!